Experimental Medicine

  • Dr. Abderrezak Bouchama

  • Department
  • About Head
  • Projects
  • Publications
  • Team

The state-of-the-art animal research facilities at King Abdullah International Medical Center are designed according to international standards to ensure the safety and human care of research animals. Three vivariums will be inaugurated in Riyadh, Dammam and Al Ahsa, respectively.

The Vivarium Research Facility provides a complete range of equipment for recombinant DNA research, and Transgenesis, together with the latest generation of optical, and SPECT Imaging and Magnetic Resonance imaging . Each vivarium is staffed with highly qualified veterinarians to ensure proper handling, care, and use of animals in scientific, human, and ethical principles.
Further, each Vivarium Research Facility is open for international accreditation and regular monitoring by the Institutional Animal Care and Use Committee.
The animal core facility is composed of 4 units namely the laboratory animals, reproductive biology and transgenesis, imaging, and experimental surgery.
The EMD contributes to KAIMRC mission namely advancement of knowledge and improvement of human health through excellent animal service-support, biomedical research and teaching.
Its function is double:
First, it functions as a service-oriented core namely to assist researchers at King Abdulaziz Medical City by providing animals and veterinary expertise as well as offering teaching in animal use for research.
Second, the Experimental Medicine Department performs its own research in various fields including heatstroke, Diabetes, and critical illnesses.  It also serves as a vital link between basic and clinical research arena.


2000 Habilitation a Diriger des Recherches (HDR): Université Paris VII

1982 Certificat d’université en Réanimation Médicale (CURM), Board equivalent, Université Paris VII

1981 Applied Medical Statistics (Certificat de Statistiques Appliqués a la Médecine:C.E.S.A.M.), University Pierre et Marie Curie, Paris VI

1981 Degree in Human Biology Studies and Research (Certificat d’Etudes et de Recherches en Biologie Humaine: C.E.R.B.H.), University of Paris VII

1977 Medical Doctor, Constantine Medical School


2010 – present Chairman & Senior Research Scientist Department of Experimental Medicine; Consultant Intensivist, Intensive Care Department
King Abdullah International Medical Research Center (KAIMRC);
King Abdul Aziz Medical City (KAMC)
Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia

2004/03-2010/01 Principal Clinical Scientist & Chairman Department of Comparative Medicine (DCM);
Consultant Intensivist
King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia

2000–2004/03 Consultant Intensivist & Joint Senior Scientist
Department of Medicine & Department of Comparative Medicine
King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia

1989 – 2000 Head, Section of Medical Surgical Intensive Care Unit (MSICU),
Department of Medicine
King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia

1987-1989 Consultant, Medical/Surgical Intensive Care Unit (MSICU), Department of Medicine
King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia

1985 – 1986 Consultant, Medical/Surgical Intensive Care Unit,
King Fahad Hospital, Jeddah, Saudi Arabia

1984 – 1985 Consultant, Medical/Surgical Intensive Care and Burn Unit,
Foch Hospital, Paris

1983 – 1984 Consultant Intensive Care Unit
Bichat University Hospital, Paris

Skills and Research Interest

Research Interests: Heat stroke, heat shock, heat exhaustion, heat stress, hyperthermia, sepsis, septic shock, inflammation

• Bouchama, A., et al., A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress. Scientific Reports, 2017. 7(1): p. 9429.

• Arabi YM, Hajeer AH, Luke T, Raviprakash K, Balkhy H, Johani S, Al-Dawood A, Al-Qahtani S, AlOmari A, Al-Hameed F, Hayden FG, Fowler R, Bouchama A, Shindo N, Al-Khairy K, Carson G, TahaY, Sadat M, Alahmadi M. Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia. Emerg Infec Dis. 2016 Sep;22(9):1554

• Mohammad S. GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus: Benefits and Challenges. Curr Drug Targets. 2015 Dec 9

• Arabi YM, Balkhy H, Hajeer AH, Bouchama A, Hayden FG, Al-Omari A, Al-Hameed F, Taha Y,Shindo N, Whitehead J, Merson L, Johani S, Al-Khairy K, Carson G, Luke T, Hensley L, Al-Dawood A,Al-Qahtani S, Modjarrad K, Sadat M, Rohde S, Leport C, Fowler R. Feasibility, Safety, Clinical andLaboratory Effects of Convalescent Plasma Therapy for Patients with Middle East Respiratory Syndrome Coronavirus Infection: A Study Protocol. Springer Plus. 2015 Nov 19;4(1):1

• Arabi YM, Harthi A, Hussein J, Bouchama A, Johani S, Hajeer AH, Saeed BT, Wahbi A, Saedy A, AL Dabbagh T, Okaili R, Sadat M, Balkhy H. Severe Neurologic Syndrome Associated with Middle East Respiratory Syndrome Corona Virus (MERS-CoV). Infection, 2015 Aug 1;43(4):495-501.

• Lisa R. Leon, Abderrezak Bouchama. Heat Stroke. Comp Physiol . 2015 April; 5:611-647. doi:10.1002/ y.c140017

• Mohammad S. Role of Free Fatty Acid receptor 2 (FFAR2) in the regulation of Metabolic Homeostasis. Current Drug Targets. 2015 Jun 1;16(7):771-5.

• Arabi YM, Dara SI, Tamim HM, Rishu AH, Bouchama A, Khedr MK, Feinstein D, Parrillo JE, Wood KE, Keenan S, Zanotti S, Martinka G, Kumar A, Kumar A. Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study. Crit Care. 2013 Apr 17;17(2):R72

• Dehbi M, Uzzaman T, Baturcam E, Eldali A, Ventura W, and Bouchama A. Toll-Like Receptor 4 and High-Mobility Group Box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke. PLOS One 04 September 2012 doi:10.1371/journal.pone.0044100

• Steffen R, Bouchama A, Johansson A, Dvorak J, Isla N, Smallwood C, Memish ZA. Noncommunicable health risks during mass gatherings. Lancet Infect Dis. 2012 Feb;12(2):142-9

• Bouchama A, Al-Mohanna F, Assad L, Baturcam E, Eldali A, Owaidah T, Dehbi M Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon. Crit Care Med. 2012 Apr;40(4):1229-36

• Arabi YM, Dehbi M, Rishu AH, Baturcam E, Kahoul SH, Brits RJ, Naidu B, Bouchama A. sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy. Crit Care. 2011 Aug 26;15(4):R203.

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