P.O. Box 3660, Riyadh 11481, Mail Code 1515 (KAIMRC)
+966 (11) 429-4444
+966 (11) 429-4440

Department of Biostatistics and Bioinformatics

  • Dr. Mohamed Hussein

  • Department
  • About Head
  • Projects
  • Team

The Department of Biostatistics and Bioinformatics focuses on research and development of computational and analytical methods essential for conducting state of the art biomedical research. The department’s researchers have diverse expertise that includes biostatistics, mathematical modeling, protein modeling, next generation omics analysis and genetic analysis.

In addition to the research and development of novel statistical and bioinformatics methods/tools, we are involved in large collaborative initiatives that cover several disease areas including diabetes and obesity, cancer, heat stress, genetic diseases and infectious diseases.

The department’s researchers work mainly through collaboration on research projects that are aligned with KAIMRC strategic initiatives. However, the department also has an outreach program that is designed to provide general statistical advice as well as systematic educational seminars, courses and workshops to clinical researchers.

Education

Ph.D. Dept. of Biostatistics & Bioinformatics School of Public health University of Louisville, “A Bayesian Model for Polytomous Ordinal Misdiagnosed Data”

MSPH. Dept. of Biostatistics & Bioinformatics  School of public health University of Louisville, “Management of Colorectal Liver Metastases: A Decision Analysis Perspective”

MSCS.  Computer Eng. & Computer Science School of Engineering University of Louisville

Experience

Chairman, Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, 2010-  Present

Assistant Professor, Department of Biostatistics and Epidemiology, King Saud bin Abdulaziz University for Health Sciences, 2010 – Present

Principal, Health Economics and Outcomes Research, Pricing and Market Access, Management consulting, IMS Health, 2007- 2010

Director, Health Economics and Outcomes Research, Pricing and Market Access, Management consulting, IMS Health

Associate Director, Health Economics and Outcomes Research, ValueMedics Research LLC, 2005- 2007

Principal Biostatistician, Pharmacoeconomics and Outcomes Research Center, Innovation Center, Humana Inc. 2003- 2005

Research Assistant, Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, 2000- 2003

Marketing Research Analyst, Rhone-Poulenc Rorer, Inc. (Currently part of Sanofi Aventis), 1997-2000

Skills

Stochastic Modeling (i.e. Markov Modeling and Discrete Time Event Modeling).

Decision trees, cost effectiveness and net benefit analyses.

Generalized Linear Models (GLM).

Micro Array Analysis.

Generalized Estimating Equation (GEE).

Survival models.

Sampling techniques and analyzing survey data.

Non-parametric statistics.

Data imputation and Missing Values.

Analysis of highly skewed distributions (i.e. cost and utilization data)

Outlier detection.

Infectious Disease

  • An alternative therapy using Placental Mesenchymal Stem Cells for treatment and management of Atherosclerosis
  • A phase II, multicenter open label study of treatment intensification with Brentiuximab -vedotin and ACVD in high risk patients with a positive interim PET after 2 cycles of ABVD
  • MERS-CoV Infection treated with A Combination of Lopinavir/ritonavir and IntErferon Beta-1b: a multicenter, placebo-controlled, double-blind randomized trial
  • Randomized Multicentre Comparative Trial to Evaluate the Long Term Effectiveness of the use of Carbaglu® in Patients with Propionic Acidemia (PA) or Methylmalonic Acidemia (MMA)
  • Computational methods for identifying somatic and germline mutations from high throughput sequencing data

Diabetes and Metabolic Disease

  • Molecular and Cellular Mechanisms Underlying Reversal of Type 2 Diabetes following Bariatric Surgery: Study using Proteomic and Genes Chip Analysis
  • Circulating MicroRNA as potential bio mercers for critical illness Myopathy
  • Discovery of potent Antimicrobial peptides acting as fusion inhibitor of the S2 subunit proteins HR1 and HR2 for MERS-CoV: A computational approach
  • Role of RORgammaT Transcription Factor in the Double Positive Thymocytes Development and Transformation
  • Transcriptome analysis of the Saudi patients suffering of Hyper Immunoglobulin E Syndrome (HIES): A surge for biomarker and therapeutic target discovery

Cancer Disease

  • Characterization of KAIMRC1 cell to discover novel breast cancer causing pathways
  • Myeloproliferative Neoplasm in Saudi Arabia (MPNR)
  • Chronic Myelogenous Leukemia (CML) Disease Registry in Saudi Arabia: An Observational Study
  • Lymph Proliferative Disorders (LPDs) Disease Registry
  • Neutrolin Catheter Lock Solution versus Heparin for locking hemodialysis catheters: A Randomized Controlled Trial

Heat Stress and Stroke

  • Gene Expression Profiling of Human Heat Stress: Effects of Aging and Gender
  • Health Impact of Extreme Heat During the Pilgrimage to Makkah: A 10 Years’ time-series Analysis
  • Application of a system biology approach to uncover the mechanisms of heat-induced exhaustion and stroke

Neurology and Psychiatric Disorder

  • Prevalence of Paternal Post-Partum Depression in Riyadh, Saudi Arabia

Methods

  • Estimating confidence limits for prevalence of misclassified events