KAIMRC, P.O Box 22490, Riyadh 11426 Saudi Arabia.
+966114294444
+966114294440

Stem Cells and Regenerative Medicine Department

  • Dr. Mohammed Abumaree
  • Ext. (84) 95584/ (84) 95504

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Research at KAIMRC Stem Cells and Regenerative Medicine Department (KSCRMD)

Cells are susceptible to malfunctioning or damage as a result of aging, injuries and diseases. Researchers at KAIMRC stem cells and regenerative medicine department (KSCRMD) are working to understand the functions of stem cells and development of diseases. Therefore, the aim is to develop therapies for diseases. Basically, we aim to restore normal function by repairing or replacing damaged or malfunctioning cells and tissues/ organs in patients suffer from diseases such as cancer, diabetes, cardiovascular, immunological, and neurological diseases.

Research at KSCRMD is bringing great advances in science, technology, health and medicine. These advances hold potential for improving approaches of disease diagnosis, prevention and the development of innovative therapies for diseases. Research at KSCRMD aims to exploit the remarkable potential that stem cells offer in advancing human health.

KAIMRC stem cell research program has a great potential to benefit us in the management of many diseases and also to improve health care in Saudi Arabia. Through stem cell research, the general public will understand the development of human body from specific and specialized stem cells and will understand the actual process that takes place from a single stem cell to an enormous group of specialized cells that allow humans to function normally.

Current stem cell research at KSCRMD will educate the general public about the development of human diseases and their treatment. This will provide the general public with more effective therapies to treat many diseases such as multiple sclerosis, atherosclerosis and cancer. Through research and knowledge about the development of normal stem cells, we can better learn how to correct the mistakes that lead to the development of such diseases.

In Saudi Arabia, there is increasing number of patients who suffer from multiple sclerosis, atherosclerosis and cancer. Therefore, our stem cell research has the potential to save many lives by preventing and treating the changes occurring during the development of these diseases. In addition, KAIMRC stem cell research will also have the potential for medical therapies by forming cells and tissues. Currently, there is increasing number of patients who are waiting for organ donation and these patients may die while waiting for an organ transplant. Therefore, KAIMRC stem cell research will provide a good source for cell replacement to treat diseases and can also possibly decrease the morbidity and mortality for those patients waiting for organ transplants.

The current stem cell research at KSCRMD will attract the world leading stem cell scientists with an outstanding research record and innovation in the field of stem cells. Stem cell research at KSCRMD is structured along several different research programs that aim to drive discoveries from the laboratory bench to the clinic. Each program focuses on a different organ system including blood, pancreas, liver, heart, and nervous system.

KSCRMD is equipped with state-of-the-art technology, which will speed up the development of stem cell based therapies. We have world class facilities for carrying out cell culture, flow cytometry, microscopy, histology, molecular biology and animal studies. These facilities allow our scientists to conduct research that spans the spectrum from basic to advanced, specialized, clinical research.

By combining the expertise of leading stem cell scientists and the use of state-of-the art-technologies, we are confident that we will offer a truthfully distinctive and influential method to form a viable platform for the development of stem cell research and stem cell based therapy in Saudi Arabia.

 

KSCRMD Stem Cell Research Program

Our research focuses on developing new therapies for major, chronic human diseases including cancer, diabetes, cardiovascular, neurological, immunological, and liver diseases. Our research program promotes active interaction between basic stem cell scientists and clinicians at KAIMRC and those at the King Abdulaziz Medical City.

Focus:
  • Isolating, characterizing and studying the therapeutic applications of stem cells derived from human adult tissues including placenta, umbilical cord blood and tissue, adipose tissue, hair follicles, bone marrow, and dental pulp;
  • Studying multipotent stem cell differentiation into a variety of cell types including hepatocytes, neurons and insulin secreting cells;
  • Developing bioengineered scaffolds to grow new tissues from stem cells;
  • Investigating the interaction between stem cells and cancer cells;
  • Determining the feasibility of human stem cells in modulating the immunopathogenic processes that underlie multiple sclerosis;
  • Exploring the therapeutic potential of stem cells in liver fibrosis and in atherosclerosis
  • Identifying new stem cell markers with potential therapeutic application such as antitumor, anti-fibrotic, anti-atherosclerotic markers.
Education

2005,PhD Reproductive Biology & Immunology Department of Obstetrics and Gynaecology- University of Auckland, Auckland, New Zealand

2001,MSC (Hons) Medical Science Department of Molecular Medicine- University of Auckland, Auckland, New Zealand

2000 Diploma Pharmacology Department of Pharmacology- University of Auckland, Auckland, New Zealand

1992 BSC Biochemistry Department of Biochemistry- King Abdulaziz University, Jeddah, Saudi Arabia

Experience

2014- present,Associate Professor College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences (KSU-HS), King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia

2007- Present Finder & Director Stem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center (KAIMRC), KAMC, MNGHA, Riyadh, Kingdom of Saudi Arabia

2011- Present,Laboratory Director College of Science and Health Professions, KSU-HS, KAMC, MNGHA, Riyadh, Saudi Arabia

2007- 2014 Assistant Professor
College of Science and Health Professions, KSU-HS, KAMC, MNGHA, Riyadh, Saudi Arabia

2004-2007 Postdoctoral Research Fellow Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand

Research Profile

Dr Mohamed Abumaree is a stem cell biologist with an educational background and research experience in human reproduction, immunology, biochemistry, pharmacology and molecular biology. He is taking a novel approach of employing advanced molecular and cellular methods to develop novel stem cell-based therapies that can prevent, diagnose and treat human diseases, such as cancers, diabetes, cardiovascular, immunological, neurological and liver diseases as well as stroke. Dr Abumaree has a special interest in mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPS). He established the department of Stem Cells and Regenerative Medicine in 2007 at KAIMRC with an ultimate mission to advance the translational research of stem cells and foster discoveries in regenerative medicine through interactions, collaboration, research support, and education. Over the past few years, Dr Abumaree has isolated and fully studied the phenotypic and functional characteristics of three different populations of MSCs from the human placenta. He found that each of these placental MSCs has unique cellular functions that can be used as a therapy to treat multiple sclerosis, atherosclerosis, thrombosis, breast cancer, diabetes and stroke.
 
Dr Abumaree has many research goals that aim to understand the biological and immunological functions of stem cells for the development of novel stem cell- based therapies. His research goals include 1) The isolation, characterization and studying the therapeutic applications of MSC isolated from human tissues including placenta, umbilical cord, adipose tissue, hair follicles, bone marrow and dental pulp; 2) The differentiation of stem cells into a variety of  cell types including hepatocytes, neurons, insulin secreting cells and others; 3) The expansion of immune cells including T and NK cells as well as antigen presenting cells from cord blood hematopoietic stem cells;  4) The development of bioengineered scaffolds to grow new tissues from stem cells; 5) Modulating the functions of cancer cells through direct communications with stem cells and through an immune cell approach; 6) Modulating the immunopathogenic processes associated with immunological and chronic diseases, and 7) The development of novel stem cell-based therapies for atherosclerosis, thrombosis, breast cancer, diabetes, stroke, multiple sclerosis and liver fibrosis.

  • Abumaree, M.H., et al., Immunomodulatory properties of human placental mesenchymal stem/stromal cells. Placenta, 2017.
  • Abumaree, M.H., et al., Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells From Decidua Parietalis of Human Term Placenta. Reproductive Sciences, 2016. 23(9). p:1193-207.
  • Abumaree, M., et al., IFPA meeting 2015 workshop report IV: placenta and obesity; stem cells of the feto-maternal interface; placental immunobiology and infection. Placenta, 2016. 48: p. S17-S20.
  • Abumaree, M.H., et al. Human placental mesenchymal stem cells (PMSCs) modulate the immunopathogenesis process in experimental autoimmune encephalomyelitis (EAE). in Multiple Sclerosis Journal. 2016.
  • Al Jumah MA, Kojan S, Al Khathaami A, Al Otibi N, Jawhary AA, Abomaray FM, Abumaree MH: Placental mesenchymal stem cells (PMSCs) modulate the differentiation and functions of macrophages in multiple sclerosis patients. Multiple Sclerosis Journal. 2016. pp. NP16-NP7.
  • Magatti M, Abumaree MH, Silini AR, Anzalone R, Saieva S, Russo E, Trapani ME, La Rocca G, Parolini O: In Vitro and In Vivo Data. Placenta: The Tree of Life 2016, 2:91.
  • Kusuma GD, Abumaree MH, Pertile MD, Perkins AV, Brennecke SP, Kalionis B: Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity. Stem Cell Reviews and Reports 2016:1-13.
  • Abomaray FM, Al Jumah MA, Alsaad KO, Jawdat D, Al Khaldi A, AlAskar AS, Al Harthy S, Al Subayyil AM, Khatlani T, Alawad AO, Alkushi A, Kalionis B, Abumaree Phenotypic and functional characterization of mesenchymal stem/multipotent stromal cells from decidua basalis of human term placenta. Stem cells international, 2016.
  • Alshareeda AT, Negm OH, Aleskandarany MA, Green AR, Nolan C, TigHhe PJ, et al. Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein. Breast Cancer Res Treat. 2016;159(1):41-53.
  • Abomaray FM, Al Jumah MA, Kalionis B, AlAskar AS, Al Harthy S, Jawdat D, Al Khaldi A, Alkushi A, Knawy BA, Abumaree Human chorionic villous mesenchymal stem cells modify the functions of human dendritic cells, and induce an anti-inflammatory phenotype in CD1+ dendritic cells. Stem Cell Reviews and Reports, 2015. 11(3): p. 423-441.
  • Abumaree, M., et al., Phenotypic and functional characterization of mesenchymal stem cells from decidua basils of human term placenta. Placenta, 2015. 36(9): p. A28.
  • Abumaree, M., et al., Human placental decidua basalis (DBMSCs) modulate the expression of receptors important in mediating the immunosuppressive functions of macrophages in cancer. Placenta, 2015. 36(9): p. A27.
  • Abumaree, M., et al. Human placental mesenchymal stem cells (pMSCs) modulate the immunopathogenesis process in experimental autoimmune encephalomyelitis (EAE). in Multiple Sclerosis Journal. 2015.
  • Abumaree, M., et al., The consequences of the interaction between chorionic villous mesenchymal stem cells and human natural killer cells. Placenta, 2015. 36(9): p. A28.
  • Abumaree, M., et al., Phenotypic and functional characterization of mesenchymal stem cells from decidua parietalis of human term placenta. Placenta, 2015. 36(9): p. A27-A28.
  • Al Jumah M, Kojan S, Al Khathaami A, Al Otaibi N, Jawhary A, Abomaray F, Alsubayyi A, Abumaree M: Placental mesenchymal stem cells (pMSCs) modulate the differentiation and functions of macrophages in multiple sclerosis patients. Multiple Sclerosis Journal. 2015. pp. 444.
  • Borg A, Yong HEJ, Lappas M, Degrelle SA, Keogh RJ, Da Silva-Costa F, Fournier T, Abumaree M, Keelan JA, Kalionis B: Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction. Reproduction 2015, 149:523-32.
  • Murthi, P., M. Abumaree, and B. Kalionis, Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis. New therapeutic targets for human placental angiogenesis diseases, 2015: p. 60.
  • Kusuma GD, Menicanin D, Gronthos S, Manuelpillai U, Abumaree MH, Pertile MD, Brennecke SP, Kalionis B: Ectopic bone formation by mesenchymal stem cells derived from human term placenta and the decidua. PloS one 2015, 10:e0141246.
  • Kusuma G, Manuelpillai U, Abumaree M, Pertile M, Brennecke S, Kalionis B: Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles. Placenta 2015, 36:312-21.
  • Kusuma G, Menicanin D, Gronthos S, Abumaree M, Brennecke S, Kalionis B: Mesenchymal stem cells derived from human term, fetal chorionic villi and the maternal decidua produce ectopic bone in vivo. Placenta 2015, 36:A29.
  • Liu H, Murthi P, Qin S, Kusuma GD, Borg AJ, Knöfler M, Haslinger P, Manuelpillai U, Pertile MD, Abumaree M: A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies. Reproductive Sciences 2014, 21:1382-94.
  • Abumaree, M., et al., IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Placenta, 2014. 35: p. S15-S19.
  • Abumaree, M., et al., IFPA Meeting 2013 Workshop Report I: Diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology. Placenta, 2014. 35: p. S4-S9.
  • Chamley L, Holland O, Chen Q, Viall C, Stone P, Abumaree M: Review: where is the maternofetal interface? Placenta 2014, 35:S74-S80.
  • Abumaree, M.H., et al., Stem Cell Research and Regenerative Medicine at King Abdullah International Medical Research Center. Stem cells and development, 2014. 23(S1): p. 12-16.
  • Abumaree, M., et al., Trophoblast debris shifts macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages: an aid to the immunosuppressive environment of human pregnancy. Placenta, 2013. 34(9): p. A28.
  • Abumaree, M., et al., Human placental mesenchymal stem cells (pMSCs) play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages. Stem Cell Reviews and Reports, 2013. 9(5): p. 620-641.
  • Abumaree, M., et al., Human placental mesenchymal stem cells (pMSCs) shift macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages: possible implication in inflammatory diseases. Placenta, 2013. 34(9): p. A28-A29.
  • Abumaree, M., et al., Phenotypic and functional characterization of mesenchymal stem cells from chorionic villi of human term placenta. Stem Cell Reviews and Reports, 2013. 9(1): p. 16-31.
  • Abumaree, M.H., et al., The rate of trophoblast shedding/deportation alters with increasing gestational age: An in vitro model to quantify trophoblast deportation. Asian Pacific Journal of Reproduction, 2013. 2(1): p. 1-7.
  • Al Jumah M, Abomaray F, Kojan S, Al Khathaami A, Abumaree M: Placental mesenchymal stem cells (pMSCs) shift the differentiation of monocytes from multiple sclerosis patients from inflammatory M1 to anti-inflammatory M2 macrophages: an aid to the immunosuppressive environment in multiple sclerosis. Multiple Sclerosis Journal. 2013. pp. 149.
  • Pathirage NA, Cocquebert M, Sadovsky Y, Abumaree M, Manuelpillai U, Borg A, Keogh RJ, Brennecke SP, Brion DE, Fournier T: Homeobox gene transforming growth factor β induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic Fetal Growth Restriction. Molecular human reproduction 2013:gat042.
  • Kusuma G, Abumaree M, Brennecke S, Kalionis B: Decidual mesenchymal stem cells have reduced resistance to oxidative stress in preeclampsia, which is restored by the aldehyde dehydrogenase agonist Alda-1. Placenta 2013, 34:A10.
  • Chui A, Kalionis B, Abumaree M, Cocquebert M, Fournier T, Evain-Brion D, Brennecke SP, Murthi P: Downstream targets of the homeobox gene DLX3 are differentially expressed in the placentae of pregnancies affected by human idiopathic fetal growth restriction. Molecular and cellular endocrinology 2013, 377:75-83.
  • Chamley L, Holland O, Chen Q, Viall C, Stone P, Abumaree M: Where is the maternofetal interface? Placenta 2013, 30:e7.
  • Holland O, Medvedeva N, McDowell-Hook M, Abumaree M, Chamley L: Syncytial nuclear aggregates, carriers of fetal alloantigens. Journal of Reproductive Immunology 2012, 94:118.
  • Abumaree, M., et al., Immunosuppressive properties of mesenchymal stem cells. Stem Cell Reviews and Reports, 2012. 8(2): p. 375-392.
  • Abumaree, M., et al., Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft? Journal of reproductive immunology, 2012. 94(2): p. 131-141.
  • Abumaree, M., P. Stone, and L. Chamley, Changes in the expression of apoptosis-related proteins in the life cycle of human villous trophoblast. Reproductive Sciences, 2012. 19(6): p. 597-606.
  • Abumaree, M.H., S. Al-Suwaidan, and R.O. Al-Kaysi, Effect of surface-modified paclitaxel nanowires on U937 cells in vitro: a novel drug delivery vehicle. Journal of Nanomaterials, 2012. p. 76.
  • Al Jumah, M.A. and M.H. Abumaree, The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS). International journal of molecular sciences, 2012. 13(7): p. 9298-9331.
  • Kusuma G, Qin S, Abumaree M, Isenmann S, Gronthos S, Dimitriadis E, Brennecke S, Kalionis B: Characterization of mesenchymal stem cell lines from the human placenta and decidua by measurement of the novel stemness marker, Aldehyde Dehydrogenase (ALDH). Placenta. 2012. pp. A57-A.
  • Castrechini N, Murthi P, Qin S, Kusuma G, Wilton L, Abumaree M, Gronthos S, Zannettino A, Gude N, Brennecke S: Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reproductive Sciences 2012, 19:1302-14.
  • Abumaree, M.H., et al., Fabrication of biologically active surface-modified Taxol nanowires using anodic aluminum oxide templates. RSC Advances, 2011. 1(5): p. 884-892.
  • Al-Sowayan B, Keogh R, Abumaree M, Al Jumah M, Brennecke SP, Kalionis B: Placental mesenchymal stem cells migrate in a placental vessel perfusion model. Placenta. pp. A67-A.
  • Chamley L, Chen Q, Ding J, Stone P, Abumaree M: Trophoblast deportation: just a waste disposal system or antigen sharing? Journal of reproductive immunology 2011, 88:99-105.
  • Abumaree, M., et al., The effects of apoptotic trophoblasts shed from placentae on monocyte differentiation: possible functions in modulating maternal immune response to the fetus. Journal of Reproductive Immunology, 2010. 86(1): p. 59-60.
  • Chamley L, Chen Q, Abumaree M, Ding J, Stone P: Trophoblast deportation–just placental debris or fetal–maternal antigen sharing? Journal of Reproductive Immunology 2010, 86:20-1.
  • Chamley, L., M. Abumaree, and P. Stone. The rate of trophoblast shedding/deportation changes with gestational age. in Placenta. 2007.