P.O. Box 3660, Riyadh 11481, Mail Code 1515 (KAIMRC)
+966 (11) 429-4444
+966 (11) 429-4440

Stem Cells and Regenerative Medicine Department

  • Dr. Mohammed Abumaree
  • Ext. (84) 95584/ (84) 95504

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Research at KAIMRC Stem Cells and Regenerative Medicine Department (KSCRMD)

Cells are susceptible to malfunctioning or damage as a result of aging, injuries and diseases. Researchers at KAIMRC stem cells and regenerative medicine department (KSCRMD) are working to understand the functions of stem cells and development of diseases. Therefore, the aim is to develop therapies for diseases. Basically, we aim to restore normal function by repairing or replacing damaged or malfunctioning cells and tissues/ organs in patients suffer from diseases such as cancer, diabetes, cardiovascular, immunological, and neurological diseases.

Research at KSCRMD is bringing great advances in science, technology, health and medicine. These advances hold potential for improving approaches of disease diagnosis, prevention and the development of innovative therapies for diseases. Research at KSCRMD aims to exploit the remarkable potential that stem cells offer in advancing human health.

KAIMRC stem cell research program has a great potential to benefit us in the management of many diseases and also to improve health care in Saudi Arabia. Through stem cell research, the general public will understand the development of human body from specific and specialized stem cells and will understand the actual process that takes place from a single stem cell to an enormous group of specialized cells that allow humans to function normally.

Current stem cell research at KSCRMD will educate the general public about the development of human diseases and their treatment. This will provide the general public with more effective therapies to treat many diseases such as multiple sclerosis, atherosclerosis and cancer. Through research and knowledge about the development of normal stem cells, we can better learn how to correct the mistakes that lead to the development of such diseases.

In Saudi Arabia, there is increasing number of patients who suffer from multiple sclerosis, atherosclerosis and cancer. Therefore, our stem cell research has the potential to save many lives by preventing and treating the changes occurring during the development of these diseases. In addition, KAIMRC stem cell research will also have the potential for medical therapies by forming cells and tissues. Currently, there is increasing number of patients who are waiting for organ donation and these patients may die while waiting for an organ transplant. Therefore, KAIMRC stem cell research will provide a good source for cell replacement to treat diseases and can also possibly decrease the morbidity and mortality for those patients waiting for organ transplants.

The current stem cell research at KSCRMD will attract the world leading stem cell scientists with an outstanding research record and innovation in the field of stem cells. Stem cell research at KSCRMD is structured along several different research programs that aim to drive discoveries from the laboratory bench to the clinic. Each program focuses on a different organ system including blood, pancreas, liver, heart, and nervous system.

KSCRMD is equipped with state-of-the-art technology, which will speed up the development of stem cell based therapies. We have world class facilities for carrying out cell culture, flow cytometry, microscopy, histology, molecular biology and animal studies. These facilities allow our scientists to conduct research that spans the spectrum from basic to advanced, specialized, clinical research.

By combining the expertise of leading stem cell scientists and the use of state-of-the art-technologies, we are confident that we will offer a truthfully distinctive and influential method to form a viable platform for the development of stem cell research and stem cell based therapy in Saudi Arabia.

 

KSCRMD Stem Cell Research Program

Our research focuses on developing new therapies for major, chronic human diseases including cancer, diabetes, cardiovascular, neurological, immunological, and liver diseases. Our research program promotes active interaction between basic stem cell scientists and clinicians at KAIMRC and those at the King Abdulaziz Medical City.

Focus:
  • Isolating, characterizing and studying the therapeutic applications of stem cells derived from human adult tissues including placenta, umbilical cord blood and tissue, adipose tissue, hair follicles, bone marrow, and dental pulp;
  • Studying multipotent stem cell differentiation into a variety of cell types including hepatocytes, neurons and insulin secreting cells;
  • Developing bioengineered scaffolds to grow new tissues from stem cells;
  • Investigating the interaction between stem cells and cancer cells;
  • Determining the feasibility of human stem cells in modulating the immunopathogenic processes that underlie multiple sclerosis;
  • Exploring the therapeutic potential of stem cells in liver fibrosis and in atherosclerosis
  • Identifying new stem cell markers with potential therapeutic application such as antitumor, anti-fibrotic, anti-atherosclerotic markers.
Education

2005,PhD Reproductive Biology & Immunology Department of Obstetrics and Gynaecology- University of Auckland, Auckland, New Zealand

2001,MSC (Hons) Medical Science Department of Molecular Medicine- University of Auckland, Auckland, New Zealand

2000 Diploma Pharmacology Department of Pharmacology- University of Auckland, Auckland, New Zealand

1992 BSC Biochemistry Department of Biochemistry- King Abdulaziz University, Jeddah, Saudi Arabia

Experience

2014- present,Associate Professor College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences (KSU-HS), King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia

2007- Present Finder & Director Stem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center (KAIMRC), KAMC, MNGHA, Riyadh, Kingdom of Saudi Arabia

2011- Present,Laboratory Director College of Science and Health Professions, KSU-HS, KAMC, MNGHA, Riyadh, Saudi Arabia

2007- 2014 Assistant Professor
College of Science and Health Professions, KSU-HS, KAMC, MNGHA, Riyadh, Saudi Arabia

2004-2007 Postdoctoral Research Fellow Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand

Research Profile

Dr Mohamed Abumaree is a stem cell biologist with an educational background and research experience in human reproduction, immunology, biochemistry, pharmacology and molecular biology. He is taking a novel approach of employing advanced molecular and cellular methods to develop novel stem cell-based therapies that can prevent, diagnose and treat human diseases, such as cancers, diabetes, cardiovascular, immunological, neurological and liver diseases as well as stroke. Dr Abumaree has a special interest in mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPS). He established the department of Stem Cells and Regenerative Medicine in 2007 at KAIMRC with an ultimate mission to advance the translational research of stem cells and foster discoveries in regenerative medicine through interactions, collaboration, research support, and education. Over the past few years, Dr Abumaree has isolated and fully studied the phenotypic and functional characteristics of three different populations of MSCs from the human placenta. He found that each of these placental MSCs has unique cellular functions that can be used as a therapy to treat multiple sclerosis, atherosclerosis, thrombosis, breast cancer, diabetes and stroke.
 
Dr Abumaree has many research goals that aim to understand the biological and immunological functions of stem cells for the development of novel stem cell- based therapies. His research goals include 1) The isolation, characterization and studying the therapeutic applications of MSC isolated from human tissues including placenta, umbilical cord, adipose tissue, hair follicles, bone marrow and dental pulp; 2) The differentiation of stem cells into a variety of  cell types including hepatocytes, neurons, insulin secreting cells and others; 3) The expansion of immune cells including T and NK cells as well as antigen presenting cells from cord blood hematopoietic stem cells;  4) The development of bioengineered scaffolds to grow new tissues from stem cells; 5) Modulating the functions of cancer cells through direct communications with stem cells and through an immune cell approach; 6) Modulating the immunopathogenic processes associated with immunological and chronic diseases, and 7) The development of novel stem cell-based therapies for atherosclerosis, thrombosis, breast cancer, diabetes, stroke, multiple sclerosis and liver fibrosis.