P.O. Box 3660, Riyadh 11481, Mail Code 1515 (KAIMRC)
+966 (11) 429-4444
+966 (11) 429-4440

Clinical Cardiovascular Research Program

  • Dr. Mouaz Al-Mallah
  • Ext.  (85) 16594

  • Department
  • About Head
  • Projects
  • Team

Cardiovascular research program is among the newly launched strategic R&D focus areas at KAIMRC. The concept of the Cardiovascular research program, similar to other strategic R&D programs, is to bring in a coordinated and well integrated fashion a set of focused R&D projects bridging basic and clinical research. It also aims to strengthen translational research with an ultimate goal to develop personalized and precision medicine for cardiovascular diseases. Some of the major focus areas include Ischemic Heart Diseases, Congestive Heart Failure, pediatric cardiology and cardiac surgery. The main objective of the program is to enhance the capacity building in cardiovascular research throughout the academic medical center and to encourage and incentivize clinicians to conduct competitive and innovative research.

One of the main focuses of the program is to investigate coronary artery disease across its spectrum including prevention, detection, and advanced therapies. Investigators in the program are exploring multiple clinical, operational and behavioral tools in the primary and secondary  prevention of coronary artery disease. In addition, investigators are utilizing advanced cardiac imaging for the early detection of coronary disease like cardiac positron emission tomography and coronary CT angiography in symptomatic patients and asymptomatic subjects. In addition, the role of new technologies in the cath lab and operating rooms like iFR is being investigated by clinical researchers. Clinical research activities in pediatric cardiology focused primarily on cardiovascular imaging, pediatric cardiovascular interventions, pulmonary hypertension and outcome research related to our active pediatric cardiac surgery program.

There are many ongoing clinical projects in the program including multicenter randomized controlled trials and investigator initiated studies. These include the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial, THIEMS trial (A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Ticagrelor 90 mg twice daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Stroke in Patients with Type 2 Diabetes Mellitus) and FLAIR study (Functional Lesion Assessment of Intermediate stenosis to guide Revascularization

Randomized Comparison of iFR to FFR). In addition, the investigators participate in multiple international registries like the ACC, STS and ESC registries

Dr Al-Mallah is currently a Consultant Cardiologist and Division Head of Cardiac Imaging at King Abdul-Aziz Cardiac Center, Ministry of National Guard Health Affairs. He is an Associate Professor of Medicine at King Saud bin Abdul Aziz University and the Head of the Cardiovascular Research Program at King Abdallah International Medical Research Center. He is also the Chairman of the Saudi Cardiac Imaging Working Group and Vice Chair of the American Society of Nuclear Cardiology International Taskforce.

Dr Mouaz Al-Mallah received his medical degree from the American University of Beirut, Lebanon. He completed his training in the USA at Henry Ford Hospital, Wayne State University, Detroit, MI; Brigham and Women’s Hospital – Harvard Medical School, Boston, MA; and the University of Michigan, Ann Arbor, MI.

Dr Al-Mallah is the head of the cardiac imaging center at King AbulAziz Cardiac Center where he established the first dedicated Cardiac PET Unit in the Middle East that routinely applied cardiac 82-Rubidium PET for the assessment of myocardial perfusion and flow reserve. Since 2011, more than 5,000 cardiac PET procedures have been performed. In addition, Dr Al-Mallah is overseeing the construction of the largest dedicated cardiac imaging center, including Nuclear Cardiology Imaging, Cardiac CT and Cardiac MRI, in the region that is expected to open in 2017.  This will be the main hub for a large enterprise of clinical, research and educational activities that will service not only the needs of the city of Riyadh, but the entire Kingdom and Gulf region.

In terms of research, Dr. Al-Mallah focused on the prognostic value of advanced cardiac imaging procedures and its impact on risk prediction, patient management and outcomes. He published on the prognostic value of cardiac CT, nuclear cardiology as well as coronary calcium score.  In addition, he is the principal investigator of the Henry Ford ExercIse Testing (FIT) Project – the largest study of physical fitness to date. It included nearly 70,000 patients with up to 22 years follow-up and is expected to answer many clinically relevant questions related to exercise capacity and prognosis.  Dr Al-Mallah has more than 180 published original publications and received multiple grants.

He is a member of several American and European cardiovascular councils, serving as an Associate Editor of the Journal of Cardiac CT and as a member of the Editorial Board of JACC, JACC- and EHJ-cardiovascular imaging.  Dr Al-Mallah received many local and international awards including Francis N. Fernandez Fellowship Award, King Abdullah International Medical Research Center Award in 2011, Best Teacher Award from Henry Ford Hospital, and Elite Reviewer Award for the year 2013 from JACC Journals.  In addition, many of his trainees have established academic careers and received multiple research awards while working under his supervision.

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