Publication Details

Title :

Prognostic value of chronic total occlusions detected on coronary computed tomographic angiography



Impact Factor:



Opolski MP1, Gransar H2, Lu Y3, Achenbach S4, Al-Mallah MH5, Andreini D6, Bax JJ7, Berman DS6, Budoff MJ8, Cademartiri F9, Callister TQ10, Chang HJ11, Chinnaiyan K12, Chow BJ13, Cury RC14, DeLago A15, Feuchtner GM16, Hadamitzky M17, Hausleiter J18, Kaufmann PA19, Kim YJ20, Leipsic JA21, Maffei EC22, Marques H23, Pontone G6, Raff G12, Rubinshtein R24, Shaw LJ25, Villines TC26, Gomez M3, Jones EC3, Peña JM3, Min JK3, Lin FY3.


1 Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.

2 Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, California, USA.

3 Dalio Institute of Cardiovacular Imaging, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, USA.

4 Department of Medicine, University of Erlangen, Erlangen, Germany.

5 King Abdullah International Medical Research Center, King AbdulAziz Cardiac Center, Riyadh, Saudi Arabia.

6 Department of Clinical Sciences and Community Health, University of Milan, Centro Cardiologico Monzino, IRCCS Milan, Milan, Italy.

7 Department of Cardiology, Leiden University Medical Center, HARTZ, Leiden, The Netherlands.

8 Department of Medicine, Harbor UCLA Medical Center, Los Angeles, California, USA.

9 Department of Radiology, SDN IRCCS Cardiovascular Imaging Center, Naples, Italy.

10 Tennessee Heart and Vascular Institute, Hendersonville, Tennessee, USA.

11 Division of Cardiology, Severance Cardiovascular Hospital and Severance Biomedical Science Institute, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.

12 Department of Cardiology, William Beaumont Hospital, Royal Oaks, Michigan, USA.

13 Department of Medicine and Radiology, University of Ottawa, Ottawa, Ontario, Canada.

14 Department of Radiology, Baptist Cardiac and Vascular Institute, Miami, Florida, USA.

15 Capital Cardiology Associates, Albany, New York, USA.

16 Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria.

17 Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany.

18 Medizinische Klinik I der Ludwig-Maximilians-Universität München, Munich, Germany.

19 University Hospital, Zurich, Switzerland.

20 Seoul National University Hospital, Seoul, Republic of Korea.

21 Department of Medicine and Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

22 Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy.

23 UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal.

24 Department of Cardiology at the Lady Davis Carmel Medical Center, The Ruth and Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

25 Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.

26 Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Year of Publication:





Data describing clinical relevance of chronic total occlusion (CTO) identified by coronary CT angiography (CCTA) have not been reported to date. We investigated the prognosis of CTO on CCTA.

We identified 22 828 patients without prior known coronary artery disease (CAD), who were followed for a median of 26 months. Based on CCTA, coronary lesions were graded as normal (no atherosclerosis), non-obstructive (1%-49%), moderate-to-severe (50%-99%) or totally occluded (100%). All-cause mortality, and major adverse cardiac events defined as mortality, non-fatal myocardial infarction and late coronary revascularisation (≥90 days after CCTA) were assessed.

The distribution of patients with normal coronaries, non-obstructive CAD, moderate-to-severe CAD and CTO was 10 034 (44%), 7965 (34.9%), 4598 (20.1%) and 231 (1%), respectively. The mortality rate per 1000 person-years of CTO patients was non-significantly different from patients with moderate-to-severe CAD (22.95; 95% CI 12.71 to 41.45 vs 14.46; 95% CI 12.34 to 16.94; p=0.163), and significantly higher than of those with normal coronaries and non-obstructive CAD (p<0.001 for both). Among 14 382 individuals with follow-up for the composite end point, patients with CTO had a higher rate of events than those with moderate-to-severe CAD (106.56; 95% CI 76.51 to 148.42 vs 65.45; 95% CI 58.01 to 73.84, p=0.009). This difference was primarily driven by an increase in late revascularisations in CTO patients (27 of 35 events). After multivariable adjustment, compared with individuals with normal coronaries, the presence of CTO conferred the highest risk for adverse cardiac events (14.54; 95% CI 9.11 to 23.20, p<0.001).

The detection of CTO on non-invasive CCTA is associated with increased rate of late revascularisation but similar 2-year mortality as compared with moderate-to-severe CAD.