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Publication

Name of Poster:

Magneto-Fluorescent Iron Oxide Nanoparticles for Drug Delivery to Human Breast Cancer

Author(s):

Ali Rizwan, Hassan Bahhari, Khaled AlSaad, Rabih Al-Kaysi, Mohamed Boudjelal, and Kheireddine El-Boubbou

Conference Presented:

Microscopy Conference 2015, Gottingen, Germany

Year of Presentation:

2015

Affiliation:

King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia; Department of Basic Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz
Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia

Shortlink:

Poster will be attached soon.

Results Summary:

Here we show that the nanoparticles were successfully endocytosed and packaged into vesicles (endosomes/lysosomes) inside the cytoplasm, releasing the drug and causing rounding of cells within 2 h of Dox@Fl-PMNPs exposure and cell death within 6 h of exposure. Moreover, live cell imaging showed that Dox was delivered to the nucleus causing apoptoic cell death in relatively short period of time. These Dox@Fl-PMNPs can potentially open new opportunities for in vivo cancer therapeutic imaging and hyperthermia where they can serve as multiphoton and magnetic resonance dual-modal imaging probes.