Name of Poster:
Magneto-Fluorescent Iron Oxide Nanoparticles for Drug Delivery to Human Breast Cancer
Ali Rizwan, Hassan Bahhari, Khaled AlSaad, Rabih Al-Kaysi, Mohamed Boudjelal, and Kheireddine El-Boubbou
Microscopy Conference 2015, Gottingen, Germany
Year of Presentation:
King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia; Department of Basic Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz
Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia
Poster will be attached soon.
Here we show that the nanoparticles were successfully endocytosed and packaged into vesicles (endosomes/lysosomes) inside the cytoplasm, releasing the drug and causing rounding of cells within 2 h of Dox@Fl-PMNPs exposure and cell death within 6 h of exposure. Moreover, live cell imaging showed that Dox was delivered to the nucleus causing apoptoic cell death in relatively short period of time. These Dox@Fl-PMNPs can potentially open new opportunities for in vivo cancer therapeutic imaging and hyperthermia where they can serve as multiphoton and magnetic resonance dual-modal imaging probes.