Nanoparticles comprise core containing iron(III) oxide and metal oxide, where core has average diameter of 2-10 nm, and surface coating containing carboxylate that chelates to surface of core and amine that binds the surface of the core. Nanoparticles are monodisperse and non-agglomerated, and have a saturation magnetization of less than or equal to 80 emu/g.
USE – Metal oxide nanoparticles for nanocolloid. Can be used in drug delivery, magnetic markers for diseased cells, and magnetic cell separation in biological samples.
ADVANTAGE – The core is crystalline with a high degree of magnetic ordering and crystallinity, providing advantageous properties for use as contrast agents in magnetic resonance imaging. The preparation method of nanoparticles is versatile because it uses water as solvent, permitting the use of hydrophobic, hydrophilic, and/or amphiphilic surfactants, and surfactants with lower boiling points. In addition, the method allows for production of ultra-small nanoparticles with hydrophobic or hydrophilic surface coating in one step in a safe, efficient, and economical manner.