Study the Characteristic of Human Mesenchymal Stem Cells in an Atherosclerotic Plaque using Preeclamptic Placenta as a Model of Atherosclerosis

Research Summary

Preeclampsia (PE) is the most important medical disorder of human pregnancy and a leading cause of maternal and fetal mortality and morbidity worldwide. PE is characterised by hypertension and shares many pathophysiological features and have common risk factors with atherosclerosis, such as the involvement of oxidative stress, endothelial dysfunction and the formation of plaque-like lesions in the placenta specifically in the decidua. Understanding the processes leading to acute atherosis lesion formation in preeclampsia will provide important insights into preeclampsia and improve our understanding of plaque formation in atherosclerosis. One feature of atherosclerosis and preeclampsia is endothelial dysfunction. Oxidative stress is important in the cause of endothelial dysfunction in preeclampsia and atherosclerosis. Mesenchymal stem cells (MSCs) are closely associated with endothelial cells that line vessel walls in the decidua, which is a major source of oxidative stress products in preeclampsia. Decidua mesenchymal stem cells (DMSCs) are exposed to the products of oxidative stress that cause endothelial dysfunction. Therefore, in this study, we aim to determine the functional properties of DMSCS. The results of this study will describe the roles of stem cells in PE and will lead to the identification of new therapeutic strategies that can improve the maternal symptoms of PE and reduce premature delivery. This study will also lead to the development of novel strategies to prevent atherosclerosis.

Photomicrographs (A) MSC isolated from human decidua placenta (DBMSCs) and (B) a colony forming unit of DBMSCs. Scale bars represent 100 µm (Abomaray et al., 2016).