Medical Research Core Facilities & Platforms

  • Overview
  • Objectives
  • Research Projects
  • Services
  • Team
  • Contact Details

The Medical Research Core Facility and Platforms serve the MNG-HA scientific community’s needs for reagents, assays, samples and data analysis for the conduct of research projects.

The Medical Research Core Facility and Platforms is comprised of the following units: Cell & Tissue Culture, Biochemical & Molecular Biology, Drug Discovery, Immunology, Light & Electron Microscopy and Mass Spectrometry and Medicinal Chemistry. Each unit has specific purpose and contribution to support the researchers.

To provide researchers with:

  • Customized Research Reagents: Cell lines, Proteins etc.
  • Services in Cell Culture, Proteomics & Metabolomics, Cell Imaging, Microscopy, Drug Screening, Medicinal Chemistry, Analytical Chemistry, Protein Expression etc.
  • Laboratory space fully equipped with the latest research platforms
  • Assist researchers in the conduct of their biomedical research in a safe environment.
  • Drug Discovery
    • Aptamer generation for MERS-CoV therapy and diagnosis
    • Nanoparticle-based virus and bacteria diagnosis
    • Antibody drug conjugate for cancer and immune-inflammation
    • Small molecules for MERS-COV
    • Small molecules for Cancer therapy
  • Cancer Research
    • Drug repurposing for leukemia treatment
    • Screening Natural products as anticancer agents for leukemia and breast cancer
    • Establishing new immortalized cell lines from patient samples and studying the mechanism of action of known drugs.
    • Role of Molecular Clock in cancer progression
  • Rare Diseases Research
    • Discovery mechanism of action of certain genes involved in rare diseases
    • Discovery of Metabolomics and Proteomic changes in rare diseases
    • Discovery of novel biomarkers for early delectation
  • Cardiovascular Research
    • Discovery of new pathways implicated in hypertension and vascular damages.    Mechanism of action of certain genes involved in rare diseases
    • Discovery of novel biomarkers for cardiovascular diseases related to endothelial dysfunction and vascular remodeling.
  • Cell Culture Facility
    • Primary and Cell lines Culture
    • Stem Cell Differentiations
    • Stable Cell line generation
    • Transfection
    • PBMC Isolation
  • Biochemistry, Microbiology and Molecular Biology Lab
    • Plasmid/DNA/RNA/Protein Extraction and their bioanalysis (western blot, gel electrophoresis)
    • PCR, PC-RFLP, qPCR
    • Recombinant protein Expression & Purification
  • Lentivirus and Baculovirus Lab
    • Lentivirus for shRNA expression for gene knock-down
    • Lentivirus for gene overexpression
    • Lentivirus for cell stable-labeling
  • Bio-Imaging Suite
    • Life Technologies EVOS FL system equipped with life cell imaging capability
    • Molecular Devices Image Express High Content Imaging System
    • Imaging using Image Express (Molecular Devices)
    • Jeol JEM-1400 Transmission Electron Microscope (TEM)
    • FEI Nova SEM Scanning Electron Microscope (SEM)
    • Zeiss LSM 780 Laser Scanning Confocal Microscope (cLSM) with life cell imaging capability
    • Nikon Total Internal Reflection Fluorescence Microscope system (TIRF)
    • Zeiss Laser Capture Microdissection (LCM) system equipped with PALM Micro Tweezers and life cell imaging capability
  • Immunology and Flow-Cytometry Platform
    • Fluorescence-activated cell analysis and sorting
    • BD FACS Canto II: Quantitative and qualitative analysis and characterization of cells, molecules and particles
    • MoFlo XDP Cell Sorter: Cell Analysis and Isolation from human or animal model.
    • Bio-Plex® 3D Suspension Array System: High-throughput testing for nucleic acid and protein applications
    • Cell Culture: Services for culture of different cell lines available in Core Lab department
  • Mass Spectrometry
    • Discovery and Targeted Proteomics
    • Discovery and Targeted Metabolomics
    • Molecular weight determination
    • Analysis of compounds for structural elucidation
    • Impurity Analysis
  • Drug Discovery, Medicinal & Analytical Chemistry
    • Design and Synthesis of Biologically Active Compounds
    • Optimization of Drug Candidates and SAR Development
    • Purification and Identification of Small Molecule
    • Antibody Drug Conjugates Preparation
    • PET Tracer Design
    • Consultancy on API Synthesis
    • Assay Development
    • Lentivirus based shRNA
    • Plate readers: Fluorescence, FRET, Luminescence etc.
    • Disease specific assay: Reporters, Colony Formation, Primary Cell Culture, Stable Cell line generations, etc.
  • Antibody Generation – Coming Soon