- Research Projects
- Contact Details
The Immunology Research Program at KAIMRC works to understand the mechanisms that underlie the pathology seen in patients with primary immunodeficiency and immune dysregulation. Approaches include development of novel models for immunodeficiency and autoimmunity. These model systems are used to determine how the immune system works to protect our body from infections and to understand how this system regulates to prevent cancer and autoimmunity.
The mission of this program is to create an interdisciplinary environment in which important scientific questions in immunology can be addressed and the development of new immunotherapeutic strategies for facilitating the treatment of the disorders of the immune system.
The program achieves this goal by providing resources and activities that foster meaningful interactions among and between basic immunology researchers and clinicians. The Program nurtures these interactions by assisting in the training of young scientists who will pursue careers in immunology and by providing forums for the exchange of scientific ideas.
Immunodeficiency and Dysregulation Project:
In this project, we evaluate the immune system to discover the defect of various primary immunodeficiency disorders, immune dysregulation and autoimmunity. This approach will guide us for discovering novel therapeutic approach for these disorders.
This evaluation includes:
- In vitro cell differentiation to TH1, TH2, TH17, TFH, Treg and other cells.
- Apoptosis and cell anergy
- Cytotoxic cell activity
- Adhesions and cell migration
- Central and peripheral tolerance
- Cell co-culturing and interaction
- Characterization of Different immune cells
- Protein expression by flow cytometry and immunoblotting
Cancer Immunity Project:
This project helps in advancing our scientific knowledge about cancer immunity that focuses on establishing novel anticancer therapies.
- T Cell checkpoints inhibitors
- Adoptive T cell therapy
- Dendritic Cells based vaccines
- Neoantigens and peptide vaccines
- Cancer cell vaccine
- Oncolytic virotherapy
The microbiota has a fundamental role in our immune system. Dysregulation of the normal microbiota is concerning for developing multiple diseases and fixing this abnormality is an important recent therapeutic approach.
Microbiota evaluation includes:
- Viral metagenomics and metatranscriptomics.
- Fungal genomics and diversity analysis
- Bacterial genomics and diversity analysis
Antibody production Project:
- Recombinant antibody production for cancer immunotherapy and human viruses.
- Monoclonal antibodies production for cancer immunotherapy and human viruses